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Understanding Off-label Drug Use: Risks & Benefitts Recent federal and state lawsuits claimed that pharmaceutical company Abbott Laboratories marketed its drug, Depakote, for off-label uses. Depakote, an anti-seizure and mood-stabilizing drug, is approved by the FDA to treat epilepsy, bipolar disorder and to prevent migraines. Earlier this year, Abbott said it will pay $1.6 billion to settle ... Depakote and Depakote ER: Side effects, dosage, and more Depakote ER (extended-release) tablets are approved to: treat manic and mixed episodes related to bipolar disorder in adults help prevent migraine in adults treat certain types of seizures (complex...

Depakote Lawsuits, Verdicts and Settlements - Drugwatch Abbott paid $1.5 billion to the federal government and 24 states for promoting Depakote for off-label use. This was the second largest settlement paid by a drug company at the time. Guilty Plea. In 2012, Abbott pleaded guilty to a federal charge of misbranding Depakote.

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Valproate (Depakote) | NAMI: National Alliance on Mental Illness Anticonvulsant medications such as phenytoin (Dilantin®), carbamazepine (Tegretol®/Carbatrol®/Equetro®), rufinamide (Banzel®), ethosuxamide (Zarontin®), and especially lamotrigine (Lamictal®). Diazepam (Valium®) Valproate may decrease the level and effects of: Olanzapine (Zyprexa®) Oxcarbazepine (Trileptal®) Depakote and Depakote ER Dosage: When to Use and More - Healthline Depakote is a prescription medication used to: treat focal impaired awareness seizures (also called complex partial seizures) in adults and some children treat absence seizures in adults and some... A survey of the off-label use of mood stabilizers in a large ... by C Haw · 2005 · Cited by 59 — When prescribing off-label, psychiatrists should consider the evidence that the drug is likely to be effective for the unlicensed indication. Where there is ...

Depakote off label uses. Valproate - Wikipedia Valproate ( VPA) and its valproic acid, sodium valproate, and valproate semisodium forms are medications primarily used to treat epilepsy and bipolar disorder and prevent migraine headaches. [2] They are useful for the prevention of seizures in those with absence seizures, partial seizures, and generalized seizures. [2] Consequences of Rampant Off-Label Prescribing of Depakote "As a clinical investigative psychiatrist," he states, "my concern is that Depakote is widely used on and off-label for so many neuropsychiatric conditions." "It has widespread use," he notes, "for... Long-Term Effects of Depakote | Healthy Living Depakote is the brand name for divalproex sodium, an anti-seizure medication given for those suffering from epilespy, other conditions that cause seizures, migraines and the manic phase in bipolar disorder. ... but those are off-label uses. Depakote has been on the market for more than 30 years, and some side effects from long-term use are ... Depakote ER Uses, Side Effects & Warnings - Drugs.com Depakote ER tablets and capsules are used to treat seizures in people with epilepsy who are at least 10 years old. This medicine tablets are sometimes used together with other seizure medications. Depakote ER tablets are also used in adults to prevent migraine headaches, or to treat manic episodes related to bipolar disorder (manic depression ).

Valproic Acid - StatPearls - NCBI Bookshelf Valproic acid is an anticonvulsive and mood stabilizer medication. It is extensively used in the adult population to treat convulsions, migraines, and bipolar disorders. This activity will highlight the mechanism of action, adverse event profile, and other key factors (e.g., off-label uses, dosing, pharmacodynamics, pharmacokinetics, monitoring, relevant interactions) pertinent for members of ... Off-label use of sodium valproate for schizophrenia - PubMed by E Horowitz · 2014 · Cited by 41 — Conclusions: Off-label use of sodium valproate in psychiatric patients with schizophrenia or schizoaffective disorder is extensive, especially ... Depakote - Psych Central Depakote (Divalproex) is an anticonvulsant used to prevent seizures. It is sometimes used in conjunction with other seizure medications. Depakote is also approved to treat bipolar disorder as well... What Your Doctor May Not Be Telling You About Depakote the fda alleged that "from 1998 through 2008, abbott unlawfully promoted depakote for unapproved uses, including behavioral disturbances in dementia patients, psychiatric conditions in children and adolescents, schizophrenia, depression, anxiety, conduct disorders, obsessive-compulsive disorder, post-traumatic stress disorder, alcohol and drug …

Depakote and the Treatment of Agitation in Alzheimer's Some physicians also prescribe it to treat the challenging behaviors in Alzheimer's disease and other types of dementia. Using valproate in this manner is considered off-label since it is not approved by the US Food and Drug Administration (FDA) for this use. Depakote: A Brief History - LawyersAndSettlements.com For the drug maker, Abbott Laboratories, sales were brisk, but there were other markets to tap into - also known as "off-label" use. Depakote has since become the most-prescribed drug (surpassing ... Off-Label Use of Sodium Valproate for Schizophrenia - PLOS by E Horowitz · 2014 · Cited by 41 — Unlike the combination of atypical antipsychotics and mood stabilizers in bipolar disorder, the use of sodium valproate in patients with ... Abbott Labs to Pay $1.5 Billion to Resolve Criminal & Civil ... The FDA approved Depakote for only three uses: epileptic seizures, bipolar mania and the prevention of migraines. The FDA never approved the drug as safe and effective for the off-label use of controlling behavioral disturbances in dementia patients.

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Depakote - What is Depakote & What is It Used For? Depakote (Divalproex Sodium) Uses The U.S. Food and Drug Administration approved Depakote in 1983 to treat epilepsy. Doctors may sometimes prescribe divalproex sodium with other medications to treat types of seizures. The FDA expanded Depakote uses to include the treatment of manic episodes associated with bipolar disorder.

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Depakote (Divalproex sodium) Oral: Uses, Side Effects, Dosages Sometimes Depakote is prescribed for off-label uses. In these cases, a doctor might prescribe Depakote for conditions not specified on the prescribing label if they deem it medically appropriate. Depakote is most commonly prescribed off-label for: 5 Schizophrenia Schizoaffective disorder Preventing pain symptoms of peripheral neuropathy 6

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Depakote Hit with Class-Action for Off-Label Marketing and Kickbacks Despite the clear labels for treatment of only the above-mentioned disorders, Abbott marketed the drug as safe and effective for an array of other uses, such as treatment of schizophrenia, aggression in dementia patients, and narcotics withdrawal. For a free legal consultation, call 800-934-6555

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7 Uses of Divalproex (Depakote) + Side Effects Divalproex sodium (brand name Depakote) is a drug that is FDA-approved to treat various types of seizures, manic episodes associated with bipolar disorder, and to help prevent migraines [ 1 ]. This medication is also sometimes used off-label to treat several other conditions including schizophrenia symptoms and depression [ 2 ].

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PDF Depakote (divalproex sodium) Tablets The safety and effectiveness of Depakote for long-term use in mania, i.e., more than 3 weeks, has not been systematically evaluated in controlled clinical trials. Therefore, healthcare providers who elect to use Depakote for extended periods should continually reevaluate the long-term usefulness of the drug for the individual patient. 1.2 Epilepsy

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Valproate (Depakote): Uses, How it works, Dosage, Side Effects Valproate (Depakote) is an anticonvulsant approved for the treatment of mania associated with bipolar disorder (also known as manic depression), seizures (epilepsy), and migraine headaches. Bipolar disorder involves episodes of depression and/or mania. Valproate (Depakote) may also be helpful when prescribed "off-label" for diabetic ...

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Depakote OFF-LABEL SEARCH - GoToPills.com Off-label Uses • Long-term use for mania (more than 3 weeks). GoToSource • Use in patients under the age of 10. GoToSource • Acute treatment of migraine headaches. GoToSource • Alcohol withdrawal and relapse prevention. GoToSource • Behavioral problems in patients with congenital rubinstein-taybi syndrome. GoToSource

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Valproate Information | FDA They are also used off-label (for unapproved uses) for other conditions, particularly for other psychiatric conditions. Valproate products include: valproate sodium (Depacon), divalproex sodium...

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Depakote?... | Bluelight.org StaySedated. my doc just gave me some Depakote (to help with benzo tapering related psychological problems), which is a GABA increasing mood stabilizer (usually for mania and depression related to bipolar disorder), anticonvulsant, and anxolytic/sedative. it acts as a GABA-T inhibitor to be specific. i noticed at around 500mg it gives a feeling ...

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The Largest Drug Settlements in U.S. History to Date Off-label uses mean that the drug company said it could be used for conditions that were outside of what the United States Food and Drug Administration's agreed to for the drugs. Depakote Off-Label Use. In another instance of off-label use, Abbott Laboratories was in violation of the False Claims Act in 2012 due to their actions. ...

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Off-Label Use of Sodium Valproate for Schizophrenia - NCBI Off-label use of a drug not according to its regulatory labeling has become common in medicine, especially in the field of psychiatry. Mood stabilizers are intended to be used to attenuate mood fluctuations in bipolar disorder, but their use has spread to patients with schizophrenia, as it provides greater control of impulsivity and aggressiveness.

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Depakote - FDA prescribing information, side effects and uses Depakote is indicated for prophylaxis of migraine headaches in adults. Depakote tablets are administered orally. The recommended starting dose is 250 mg twice daily. Some patients may benefit from doses up to 1,000 mg/day. In the clinical trials, there was no evidence that higher doses led to greater efficacy. 2.4 General Dosing Advice

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Depakote Withdrawal Help | Valproic Acid Side Effects, Treatment Depakote is sometimes used as an adjunctive or add-on medication in the management of schizophrenia, psychosis, or other psychiatric disorders. particular caution is advised when other medications are prescribed as they may slow or speed up the rate at which Depakote is metabolized.

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A survey of the off-label use of mood stabilizers in a large ... by C Haw · 2005 · Cited by 59 — When prescribing off-label, psychiatrists should consider the evidence that the drug is likely to be effective for the unlicensed indication. Where there is ...

35 Depakote Off Label Uses - Modern Label Ideas

Depakote and Depakote ER Dosage: When to Use and More - Healthline Depakote is a prescription medication used to: treat focal impaired awareness seizures (also called complex partial seizures) in adults and some children treat absence seizures in adults and some...

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Valproate (Depakote) | NAMI: National Alliance on Mental Illness Anticonvulsant medications such as phenytoin (Dilantin®), carbamazepine (Tegretol®/Carbatrol®/Equetro®), rufinamide (Banzel®), ethosuxamide (Zarontin®), and especially lamotrigine (Lamictal®). Diazepam (Valium®) Valproate may decrease the level and effects of: Olanzapine (Zyprexa®) Oxcarbazepine (Trileptal®)

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